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dc.contributor.authorRoy, Élisefr
dc.contributor.otherBruneau, Juliefr
dc.contributor.otherZang, Gengfr
dc.contributor.otherAbrahamowicz, Michalfr
dc.contributor.otherJutras-Aswad, Didierfr
dc.contributor.otherDaniel, Markfr
dc.identifierPMID: 24363333fr
dc.description.abstractBACKGROUND: Notification of hepatitis C virus (HCV) positive status is known to have short-term impacts on subsequent alcohol, drug use and injection behaviors among persons who inject drugs (PWID). It remains to be established whether post-screening behavioral changes extend over time for PWID and whether screening test notification has behavioral impacts among HCV-negative PWID. This study sought to longitudinally assess substance use and injection behaviors after HCV status notification among HCV seroconverters and HCV-negative PWID. METHODS: Initially HCV-seronegative PWID (n = 208) were followed prospectively between 2004 and 2011 in Montreal, Canada. Semi-annual screening visits included blood sampling and an interview-administered questionnaire assessing substance use and injection behaviors. Multivariable generalized estimating equation analyses were conducted to assess substance use and behavior changes over time and compare changes between HCV seroconverters and HCV-seronegative participants while adjusting for baseline characteristics. RESULTS: Of the 208 participants (83% male; mean age, 34.7 years, mean follow-up time, 39 months), 69 (33.2%) seroconverted to HCV. A linear decrease in syringe sharing behavior was observed over time after HCV and status notification, whereas a 10% decrease for each additional 3 months of follow-up was observed for injection cocaine and heroin use among HCV seroconverters but not among HCV-seronegative PWID (P < .05). No significant changes were observed in alcohol use. CONCLUSIONS: Our results indicate that notification of HCV-positive status is associated with reduced injection drug use among seroconverters. Among PWID deemed seronegative after screening, there is no sustained trend for change in risk
dc.relation.ispartofClinical Infectious Diseasesfr
dc.relation.isversionofdoi: 10.1093/cid/cit938
dc.rightsAttribution - Pas d’Utilisation Commerciale - Pas de Modification 2.5 Canada*
dc.subjectBehavior changefr
dc.subjectHepatitis Cfr
dc.subjectInjection drug usefr
dc.titleSustained drug use changes following hepatitis C screening and counseling among recently infected persons who inject drugs: a longitudinal studyfr
udes.description.typepubRévisé et accepté par des pairsfr
udes.description.diffusionDiffusé par Savoirs UdeS, le dépôt institutionnel de l'Université de Sherbrookefr
dc.identifier.bibliographicCitationBruneau J, Zang G, Abrahamowicz M, Jutras-Aswad D, Daniel M, Roy E. Sustained drug use changes after hepatitis C screening and counseling among recently infected persons who inject drugs: a longitudinal study. Clin Infect Dis. 2014 Mar;58(6):755-61. doi: 10.1093/cid/cit938. Epub 2013 Dec
udes.description.sourceClinical Infectious Diseasesfr
udes.description.ordreauteursBruneau, Julie; Zang, Geng; Abrahamowicz, Michal; Jutras-Aswad, Didier; Daniel, Mark; Roy, Élise

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Attribution - Pas d’Utilisation Commerciale - Pas de Modification 2.5 Canada
Except where otherwise noted, this document's license is described as Attribution - Pas d’Utilisation Commerciale - Pas de Modification 2.5 Canada