• Français
    • English
  • Français 
    • Français
    • English
  • Login
View Document 
  •   Savoirs UdeS Home
  • Médecine et sciences de la santé
  • Publications et recherches – Médecine et sciences de la santé
  • Médecine et sciences de la santé – Articles de périodiques
  • View Document
  •   Savoirs UdeS Home
  • Médecine et sciences de la santé
  • Publications et recherches – Médecine et sciences de la santé
  • Médecine et sciences de la santé – Articles de périodiques
  • View Document
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of Savoirs UdeSDomains & CollectionsBy Issue DateAuthorsTitlesSubjectsDirectorsThis CollectionBy Issue DateAuthorsTitlesSubjectsDirectors

My Account

Login

Statistics

View Usage Statistics

Presence of task-1 channel in the laryngeal mucosa in the newborn lamb

Thumbnail
View/Open
Article de périodique (620.2Kb)
Publication date
2011
Author(s)
Bournival, Véronique; Roberge, Claude; Campbell, Shirley; Doueik, Alexandre; Gendron, Louis; Payet, Marcel Daniel; Gallo-Payet, Nicole; Praud, Jean-Paul
Subject
Immunohistochemistry
 
KCNK3
 
Lamb
 
Larynx
 
Respiratory epithelium
 
RT-PCR
Show full document record
Abstract
Nearly 40 potassium channels have been described in respiratory epithelial cells. Of these are found several members of the 4-transmembrane domain, 2-pore K(+) channel family (K2P family), namely Twik-1 and -2, Trek-1 and -2, Task-2, -3, and -4, Thik-1, and KCNK7. The aim of this study was to verify whether the Twik-related acid-sensitive K(+) channel, subtype 1 (Task-1) (also known as KCNK3), is present in the laryngeal mucosa in the newborn lamb. Through the use of immunohistochemistry and nested polymerase chain reaction (PCR) amplification, results indicate that Task-1 protein and mRNA are present in the laryngeal mucosa, in both the ciliated, pseudostratified columnar (respiratory) epithelium and the nonkeratinized, stratified squamous epithelium. The complete ovine Task-1 protein sequence showed high homology levels with previously reported mouse, bovine, and human Task-1 sequences. This includes a complete homology for the C-terminal amino acid sequence, which is mandatory for protein trafficking to the cell membrane. These results represent the first demonstration that Task-1, a pH-sensitive channel responsible for setting membrane potential, is present in the laryngeal mucosa of a newborn mammal.
URI
http://hdl.handle.net/11143/7961
Collection
  • Médecine et sciences de la santé – Articles de périodiques [222]

DSpace software [version 5.4 XMLUI], copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
 

 


DSpace software [version 5.4 XMLUI], copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback