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Mechanisms of active laryngeal closure during non-invasive intermittent positive pressure ventilation in non-sedated lambs

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Article de périodique (606.4Kb)
Publication date
2008
Author(s)
Roy, Bianca; Samson, Nathalie; Moreau-Bussière, François; Ouimet, Alain; Dorion, Dominique; Mayer, Sandeep; Praud, Jean-Paul
Subject
Bronchopulmonary receptors
 
Volume control ventilation
 
Video-assisted thoracic surgery
 
Upper airways
 
Vagotomy
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Abstract
The present study stems from our recent demonstration (Moreau-Bussiere F, Samson N, St-Hilaire M, Reix P, Lafond JR, Nsegbe E, Praud JP. J Appl Physiol 102: 2149-2157, 2007) that a progressive increase in nasal intermittent positive pressure ventilation (nIPPV) leads to active glottal closure in nonsedated, newborn lambs. The aim of the study was to determine whether the mechanisms involved in this glottal narrowing during nIPPV originate from upper airway receptors and/or from bronchopulmonary receptors. Two groups of newborn lambs were chronically instrumented for polysomnographic recording: the first group of five lambs underwent a two-step bilateral thoracic vagotomy using video-assisted thoracoscopic surgery (bilateral vagotomy group), while the second group, composed of six lambs, underwent chronic laryngotracheal separation (isolated upper airway group). A few days later, polysomnographic recordings were performed to assess glottal muscle electromyography during step increases in nIPPV (volume control mode). Results show that active glottal narrowing does not develop when nIPPV is applied on the upper airways only, and that this narrowing is prevented by bilateral vagotomy when nIPPV is applied on intact airways. In conclusion, active glottal narrowing in response to increasing nIPPV originates from bronchopulmonary receptors.
URI
http://hdl.handle.net/11143/7960
Collection
  • Médecine et sciences de la santé – Articles de périodiques [281]

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