Show simple document record

dc.contributor.authorDuvareille, Charlesfr
dc.contributor.authorBeaudry, Benoitfr
dc.contributor.authorSt-Hilaire, Mariefr
dc.contributor.authorBoheimier, Mathieufr
dc.contributor.authorBrunel, Cyrilfr
dc.contributor.authorMicheau, Philippefr
dc.contributor.authorPraud, Jean-Paulfr
dc.date.accessioned2015-10-13T23:16:13Z
dc.date.available2015-10-13T23:16:13Z
dc.date.created2010fr
dc.date.issued2015-10-13
dc.identifierPMID:20713426fr
dc.identifier.urihttp://hdl.handle.net/11143/7959
dc.description.abstractThe aim of this study was to describe the characteristics and validate the use of a new, custom-built automatic smoking machine (ASM), primarily designed to study the effects of an environmental tobacco smoke surrogate (ETS surrogate) exposure in animals of various sizes, including large animals. The equipment includes a programmable ASM coupled to a vented whole body chamber, where animals can be exposed to both mainstream and sidestream smoke. The user-friendly interface allows for full programming of puff volume (1-60 mL), time interval between two puffs (1-60 s) and between two cigarettes (1-60 min). Eight newborn lambs were exposed to either 10 (4 lambs, C10 group) or 20 (4 lambs, C20 group) cigarettes, 8 h per day for 15 days. Four additional control, lambs were exposed to air (C0 group). Weight gain was identical in all three groups of lambs. Urinary cotinine/creatinine ratio increased with the number of cigarettes smoked (C0: 11 ± 7 ng/mg; C10: 961 ± 539 ng/mg; C20: 1821 ± 312 ng/mg), with levels in the C10 and C20 groups in keeping with values published in infants exposed to ETS. Overall, results show that our new ASM is especially well suited for ETS surrogate exposure in non-restrained, non-anaesthetized large animals such as sheep.fr
dc.language.isoengfr
dc.relation.isformatofdoi:10.1258/la.2010.009124fr
dc.relation.ispartofISSN:0023-6772fr
dc.relation.ispartofLaboratory animalsfr
dc.subjectEnvironmental tobacco smokefr
dc.subjectMainstream smokefr
dc.subjectSidestream smokefr
dc.subjectUrinary cotininefr
dc.subjectLambfr
dc.titleValidation of a new automatic smoking machine to study the effects of cigarette smoke in newborn lambsfr
dc.typeArticlefr
dc.rights.holder© SAGE Publicationsfr
udes.description.typestatusPrépublicationfr
udes.description.typepubRévisé et accepté par des pairsfr
udes.description.pages1-33fr
udes.description.period44(4)fr
udes.description.sponsorshipCanadian Institutes of Health Researchfr
udes.description.sponsorshipFoundation of Starsfr
udes.description.sponsorshipCanada Research Chair in Neonatal Respiratoryfr
udes.description.diffusionDiffusé par Savoirs UdeS, le dépôt institutionnel de l'Université de Sherbrookefr
dc.identifier.bibliographicCitationDuvareille, C., Beaudry, B., St-Hilaire, M., Boheimier, M., Brunel, C., Micheau, P., Praud, J.-P. (2010). Validation of a new automatic smoking machine to study the effects of cigarette smoke in newborn lambs. Laboratory animals, 44(4), 290-297. doi:10.1258/la.2010.009124fr
udes.description.sourceLaboratory animalsfr
udes.autorisation.depottruefr
udes.description.ordreauteursDuvareille, Charles; Beaudry, Benoit; St-Hilaire, Marie; Boheimier, Mathieu; Brunel, Cyril; Micheau, Philippe; Praud, Jean-Paul


Files in this document

Thumbnail

This document appears in the following Collection(s)

Show simple document record