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dc.contributor.authorSamson, Nathaliefr
dc.contributor.authorNadeau, Charlènefr
dc.contributor.authorPraud, Jean-Paulfr
dc.contributor.otherHadj-Ahmed, Mohamed Aminefr
dc.contributor.otherBoudaa, Nadiafr
dc.date.accessioned2015-10-13T23:13:14Z
dc.date.available2015-10-13T23:13:14Z
dc.date.created2015fr
dc.date.issued2015-10-13
dc.identifierPMID:25660143fr
dc.identifier.urihttp://hdl.handle.net/11143/7958
dc.description.abstractBackground: We have previously shown that nasal pressure support ventilation (nPSV) can lead to an active inspiratory laryngeal narrowing in lambs. This, in turn, can limit lung ventilation and divert air into the digestive system, with potentially deleterious consequences. On the other hand, nasal high-frequency oscillatory ventilation (nHFOV) is particularly attractive in newborns, especially since, unlike nPSV, it does not require synchronization with the patient's inspiratory efforts. Objectives: The main aim of the present study was to test the hypothesis that glottal constrictor muscle activity (EMG) does not develop during nHFOV. A secondary objective was to study laryngeal EMG during nHFOV-induced central apneas. Methods: Polysomnographic recordings were performed in 7 nonsedated lambs which were ventilated with increasing levels of nPSV and nHFOV at both 4 and 8 Hz, in random order. States of alertness, diaphragm and glottal muscle EMG, SpO2, and respiratory movements were continuously recorded. Results: While phasic inspiratory glottal constrictor EMG appeared with increasing nPSV levels in 6 out of 7 lambs, it was never observed with nHFOV. In addition, nHFOV at 4 Hz dramatically inhibited central respiratory drive in 4/7 lambs, with 64-100% of recording time spent in central apnea in 3 lambs. No glottal constrictor EMG was observed during these central apneas. Conclusion: nHFOV does not induce glottal constrictor muscle EMG in nonsedated newborn lambs, in contrast to nPSV. This may be an additional advantage of nHFOV relative to nPSV.fr
dc.language.isoengfr
dc.relation.isformatofdoi:10.1159/000369120fr
dc.relation.ispartofISSN:1661-7800fr
dc.relation.ispartofNeonatologyfr
dc.subjectNasal pressure support ventilationfr
dc.subjectPolysomnographyfr
dc.subjectLaryngeal muscle activityfr
dc.subjectQuiet sleepfr
dc.subjectNasal high frequency oscillatory ventilationfr
dc.subjectCentral apneafr
dc.titleLaryngeal muscle activity during nasal high frequency oscillatory ventilation in non-sedated newborn lambsfr
dc.typeArticlefr
dc.rights.holder© Kargerfr
udes.description.typestatusPrépublicationfr
udes.description.typepubRévisé et accepté par des pairsfr
udes.description.period107(3)fr
udes.description.sponsorshipCanadian Institutes of Health Researchfr
udes.description.sponsorshipCanada Research Chair in Neonatal Respiratory Physiologyfr
udes.description.diffusionDiffusé par Savoirs UdeS, le dépôt institutionnel de l'Université de Sherbrookefr
dc.identifier.bibliographicCitationHadj-Ahmed, M. A., Samson, N., Nadeau, C., Boudaa, N., Praud, J.-P. (2015). Laryngeal muscle activity during nasal high-frequency oscillatory ventilation in nonsedated newborn lambs. Neonatology, 107(3), 199-205. doi:10.1159/000369120fr
udes.description.sourceNeonatologyfr
udes.autorisation.depottruefr
udes.description.ordreauteursHadj-Ahmed, Mohamed Amine; Samson, Nathalie; Nadeau, Charlène; Boudaa, Nadia; Praud, Jean-Paul


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