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dc.contributor.authorSamson, Nathaliefr
dc.contributor.authorRoy, Biancafr
dc.contributor.authorOuimet, Alainfr
dc.contributor.authorMoreau-Bussière, Françoisfr
dc.contributor.authorDorion, Dominiquefr
dc.contributor.authorPraud, Jean-Paulfr
dc.date.accessioned2015-10-13T23:09:13Z
dc.date.available2015-10-13T23:09:13Z
dc.date.created2008fr
dc.date.issued2015-10-13
dc.identifierPMID:18635879fr
dc.identifier.urihttp://hdl.handle.net/11143/7957
dc.description.abstractThe present study was aimed at investigating the principal reflex mechanism by which non-nutritive swallowing (NNS) is inhibited by application of a nasal CPAP 6 cm H2O during quiet sleep (QS) in newborn lambs. Eighteen full-term lambs were chronically instrumented and evenly distributed into 3 separate groups to sort out whether reflex activity originates from the upper or lower airway receptors. Six lambs were tracheotomized, six other lambs underwent a 2-step bilateral intrathoracic vagotomy while the remaining 6 lambs underwent chronic laryngo-tracheal separation (isolated upper airway group). Forty-eight hours after surgery, each nonsedated lamb underwent polysomnographic recordings on 3 consecutive days. States of alertness, NNS and respiratory movements were recorded. Results demonstrate that a CPAP of 6 cm H2O inhibited NNS during QS while administered directly on the lower airways. This NNS inhibition was prevented by eliminating the vagal afferent messages originating from the bronchopulmonary receptors. However, application of CPAP on the upper airways only also inhibited NNS during QS. Finally, the application of a CPAP 6 cm H2O had no systematic effect on NNS-breathing coordination. In conclusion, our results suggest that the inhibiting effect of nasal CPAP 6 cm H2O on NNS is mainly mediated by bronchopulmonary receptors with some participation however of upper airway receptors. Our demonstration that spontaneous, non-nutritive swallowing can be modulated by bronchopulmonary receptor activity further illustrates the physiological interactions between upper and lower airways.fr
dc.language.isoengfr
dc.relation.isformatofdoi:10.1152/japplphysiol.90494fr
dc.relation.ispartofISSN:8750-7587fr
dc.relation.ispartofJournal of applied physiologyfr
dc.subjectNasal and tracheal continuous positive airway pressurefr
dc.subjectVagotomyfr
dc.subjectLaryngotracheal separationfr
dc.subjectBronchopulmonary receptorsfr
dc.titleOrigins of the inhibiting effects of nasal CPAP on non-nutritive swallowing in newborn lambsfr
dc.typeArticlefr
dc.rights.holder© American Physiological Societyfr
udes.description.typestatusPost-publicationfr
udes.description.typepubRévisé et accepté par des pairsfr
udes.description.period105(4)fr
udes.description.sponsorshipCanadian Institutes for Health Researchfr
udes.description.sponsorshipFoundation of Starsfr
udes.description.diffusionDiffusé par Savoirs UdeS, le dépôt institutionnel de l'Université de Sherbrookefr
dc.identifier.bibliographicCitationSamson, N., Roy, B., Ouimet, A., Moreau-Bussière, F., Dorion, D., Mayer, S., Praud, J.-P. (2008). Origins of the inhibiting effects of nasal CPAP on nonnutritive swallowing in newborn lambs. Journal of applied physiology, 105(4), 1083-1090. doi:10.1152/japplphysiol.90494fr
udes.description.sourceJournal of applied physiologyfr
udes.autorisation.depottruefr
udes.description.ordreauteursSamson, Nathalie; Roy, Bianca; Ouimet, Alain; Moreau-Bussière, François; Dorion, Dominique; Praud, Jean-Paul


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