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dc.contributor.authorCarreau, Anne-Mariefr
dc.contributor.authorSamson, Nathaliefr
dc.contributor.authorDoueik, Alexandre A.fr
dc.contributor.authorHamon, Juliefr
dc.contributor.authorFortier, Pierre-Huguesfr
dc.contributor.authorPraud, Jean-Paulfr
dc.contributor.otherPatural, Huguesfr
dc.date.accessioned2015-10-13T22:13:30Z
dc.date.available2015-10-13T22:13:30Z
dc.date.created2011fr
dc.date.issued2015-10-13
dc.identifierPMID:21636560fr
dc.identifier.urihttp://hdl.handle.net/11143/7950
dc.description.abstractIt has been suggested that reflux laryngitis (RL) is involved in apneas-bradycardias of the newborn. The aim of the present study was to develop a unique RL model in newborn lambs to test the hypothesis that RL enhances the cardiorespiratory components of the laryngeal chemoreflexes (LCR) in the neonatal period. Gastric juice surrogate (2 ml of normal saline solution with HCl pH 2 + pepsin 300 U/ml) (RL group, n = 6) or normal saline (control group, n = 6) was repeatedly injected onto the posterior aspect of the larynx, 3 times a day for 6 consecutive days, via a retrograde catheter introduced into the cervical esophagus. Lambs instilled with gastric juice surrogate presented clinical signs of RL, as well as moderate laryngitis on histological observation. Laryngeal chemoreflexes were thereafter induced during sleep by injection of 0.5 ml of HCl (pH 2), ewe's milk, distilled water or saline into the laryngeal vestibule via a chronic, transcutaneous supraglottal catheter. Overall, RL led to a significantly greater respiratory inhibition compared with the control group during LCR, including longer apnea duration (P = 0.01), lower minimal respiratory rate (P = 0.002), and a more prominent decrease in arterial hemoglobin saturation (SpO(2)) (P = 0.03). No effects were observed on cardiac variables. In conclusion, 1) our unique neonatal ovine model presents clinical and histological characteristics of RL; and 2) the presence of RL in newborn lambs increases the respiratory inhibition observed with LCR, at times leading to severe apneas and desaturations.fr
dc.language.isoengfr
dc.relation.isformatofdoi:10.1152/japplphysiol.00105fr
dc.relation.isformatofEffects of simulated reflux laryngitis on laryngeal chemoreflexes in newborn lambs
dc.relation.ispartofISSN:8750-7587fr
dc.relation.ispartofJournal of applied physiologyfr
dc.subjectPolysomnographyfr
dc.subjectSleepfr
dc.subjectApparent life-threatening eventfr
dc.subjectApnea of prematurityfr
dc.subjectSudden infant death syndromefr
dc.titleEffects of reflux laryngitis on laryngeal chemoreflexes in newborn lambsfr
dc.typeArticlefr
dc.rights.holder© American Physiological Societyfr
udes.description.typestatusPost-publicationfr
udes.description.typepubRévisé et accepté par des pairsfr
udes.description.pages1-32fr
udes.description.period111(2)fr
udes.description.sponsorshipCanadian Insitutes for Health Researchfr
udes.description.sponsorshipFoundation of Starsfr
udes.description.sponsorshipCanada Research Chair in Neonatal Respiratory Physiologyfr
udes.description.diffusionDiffusé par Savoirs UdeS, le dépôt institutionnel de l'Université de Sherbrookefr
dc.identifier.bibliographicCitationCarreau, A.-M., Patural, H., Samson, N., Doueik, A. A., Hamon, J., Fortier, P.-H., Praud, J.-P. (2011). Effects of simulated reflux laryngitis on laryngeal chemoreflexes in newborn lambs. Journal of applied physiology, 111(2), 400-406. doi:10.1152/japplphysiol.00105fr
udes.description.sourceJournal of applied physiologyfr
udes.autorisation.depottruefr
udes.description.ordreauteursCarreau, Anne-Marie; Patural, Hugues; Samson, Nathalie; Doueik, Alexandre A.; Hamon, Julie; Fortier, Pierre-Hugues; Praud, Jean-Paul


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