RSS 1.0Publications et recherches – Sciences
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Polyhedral Newton-min algorithms for complementarity problems
(Université de Sherbrooke, 2023)Abstract : The semismooth Newton method is a very efficient approach for computing a zero of a large class of nonsmooth equations. When the initial iterate is sufficiently close to a regular zero and the function is strongly ... -
Experimental evidence for spin-triplet states in Titanium implanted AlN film : an electron spin resonance study
(2023)Abstract : Spin carrying defects in wide-bandgap semiconductors are promising candidates for the development of quantum information and quantum sensing technology. Here we report experimental evidence for the formation of ... -
DNA-damaging agents induce the RecA-independent homologous recombination functions of integrating conjugative elements of the SXT/R391 family
(2013)Abstract : Integrating conjugative elements (ICEs) of the SXT/R391 family are major contributors to the spread of antibiotic resistance genes. These elements also catalyze their own diversity by promoting inter-ICE ... -
Functionalized polyhydroquinolines from amino acids using a key one-pot cyclization cascade and application to the synthesis of (±)-Δ7-mesembrenone
(2021)Substituted polyhydroquinolines are ubiquitous skeletal cores found in drugs and bioactive natural products. As a new route to access this motif, we successfully developed a one-pot cyclization cascade with high chemocontrol ... -
Mapping ecosystem services provided by wetlands at multiple spatiotemporal scales : a case study in Quebec, Canada
(2019)Abstract : Wetlands are affected by climate and anthropogenic changes, which influence the ecosystem services (ES) they provide. This study presents a spatially explicit quantification of wetland ESs. The study site is the ... -
Crop scouting using UAV imagery : a case study for potatoes
(2020)Abstract : Crop scouting is essential to manage crops such as potatoes and detect stresses. In fact, conventional approaches require a lot of time and staff. The rise of unmanned aerial vehicle (UAV) imagery offers interesting ... -
Physique statistique I
(Université de Sherbrooke, 2021)Deuxième édition avec corrections de coquilles et addition de quelques sujets. Premier cours de physique statistique à l'Université de Sherbrooke (PHQ340). Contenu: Introduction générale, Introduction aux méthodes statistiques, ... -
A geometic method for the periodic problem in ordinary differential equations
(1992)In this monograph we present foundations and basic applications of a new method for the periodic problem for ordinary differential equations. The method was introduced in [Sr2,3] and is based on the Lefschetz Fixed Point ... -
Sequential One-pot Vilsmeier–Haack and organocatalyzed Mannich cyclizations to functionalized benzoindolizidines and benzoquinolizidines
(2020)Abstract: The development of new one-pot sequential cyclizations involving a Vilsmeier–Haack reaction followed by an organocatalyzed Mannich reaction is reported. This synthetic strategy gives access to functionalized ... -
Rapid assembly of quinolizidines via consecutive nucleophilic cyclizations onto activated amides
(2011)Abstract: A new approach to the synthesis of quinolizidines involving a cascade of nucleophilic cyclizations triggered by chemoselective amide activation is reported. Particular attention was given to the effect of the ... -
Short approach toward the nonracemic A,B,E tricyclic core of calyciphylline B-type alkaloids
(2017)Abstract: A suitably functionalized tricyclic adduct containing the common A,B,E rings found in calyciphylline B-type alkaloids was obtained in nine linear steps. The key transformation features an efficient one-pot sequence ... -
General approach toward aspidospermatan-type alkaloids using one-pot Vilsmeier–Haack cyclization and azomethine ylide cycloaddition
(2017)Abstract: The development of a new one-pot reaction sequence afforded the tricyclic core of several aspidospermatan-type alkaloids from a linear, densely functionalized substrate. The key sequence features a highly ... -
Bis-michael acceptors as novel probes to study the Keap1/Nrf2/ARE pathway
Other titre : Supporting information for "Bis-michael acceptors as novel probes to study the Keap1/Nrf2/ARE pathway"(2016)Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator that promotes the transcription of cytoprotective genes in response to oxidative/electrophilic stress. Various Michael-type compounds were designed ... -
Studies toward total synthesis of (±)-caldaphnidine C via one-pot sequential intramolecular Vilsmeier–Haack and azomethine ylide 1,3-dipolar cycloaddition
(2016)An application of a one-pot sequential Vilsmeier–Haack cyclization and intramolecular azomethine ylide 1,3-dipolar cycloaddition toward the total synthesis of (±)-caldaphnidine C is presented. It allowed an efficient ... -
Preparation of conformationally restricted β2,2- and β2,2,3-amino esters and derivatives containing an all-carbon quaternary center
(2015)Abstract: β-Amino acids are routinely incorporated into peptidic drugs to increase their stability and to incur conformational biases. However, the synthesis of highly substituted β-amino acids still represents a great ... -
Asymmetric total synthesis of (+)-virosine a via sequential nucleophilic cyclizations onto an activated formamide
(2012)Abstract: The first synthesis of tetracyclic alkaloid virosine A is reported. The natural alkaloid was prepared in only 13 steps, in an enantioenriched form. The azabicyclo[2.2.2]octane core was efficiently assembled using ... -
Synthesis of the tetracyclic core of daphnilactone B-type and yuzurimine-type alkaloid
(2011)Abstract: The core of daphnilactone B-type and yuzurimine-type alkaloids was synthesized in only 16 steps from a known β-allyl-γ-butyrolactone. The key sequence of Vilsmeier–Haack cyclization and intramolecular azomethine ... -
Highly diastereoselective synthesis of substituted pyrrolidines using a sequence of azomethine ylide cycloaddition and nucleophilic cyclization
(2010)Abstract: Although cycloadditions of azomethine ylides usually give mixtures of endo/exo adducts, we successfully tuned the mechanistic path of a new reaction cascade to afford substituted pyrrolidines in high yields and ... -
A Versatile cascade of intramolecular vilsmeier-haack and azomethine ylide 1,3-dipolar cycloaddition toward tricyclic cores of alkaloids
(2008)Abstract: In the pursuit of synthetic efficiency, we developed an innovative one-pot transformation of linear substrates into bi- and tricyclic adducts using a cascade of amide activation, nucleophilic cyclization, ... -
Synthesis of the tricyclic core of alkaloid securinol B using a cascade of vilsmeier-haack and mannich cyclizations
(2008)Abstract: The Securinega alkaloids are a family of approximately 20 tetracyclic compounds isolated from diverse Securinega, Phyllanthus, and Margaritaria species of the Euphorbiaceae plant family. Most of these alkaloids ...
