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dc.contributor.authorPaquette, Benoitfr
dc.contributor.authorBoyle, Ross W.fr
dc.contributor.authorAli, Hasratfr
dc.contributor.authorVan Lier, Johannes E.fr
dc.contributor.editorUniversité de Sherbrooke. Laboratoire des sciences des radiationsfr
dc.contributor.editorPaisley College of Technology. Department of Chemistryfr
dc.contributor.otherMaclennan, Alexander H.fr
dc.contributor.otherTruscott, T. Georgefr
dc.date.accessioned2015-04-28T21:28:19Z
dc.date.available2015-04-28T21:28:19Z
dc.date.created1991fr
dc.date.issued2015-04-28
dc.identifier.urihttp://hdl.handle.net/11143/6758
dc.description.abstractThe photocytotoxicity of sulfonated phthalimidomethyl aluminum phthalocyanine, a more hydrophobic photosensitizer as compared to phthalocyanine substituted with sulfonate groups only, was investigated. Inclusion of 1-2 phthalimidomethyl groups into disulfonated aluminum phthalocyanine, resulted in increased partition coefficients between n-octanol and water, and a six-fold increase in both cellular uptake and photocytotoxicity towards Chinese hamster lung fibroblast cells (line V-79). Reducing the number of phthalimidomethyl groups, or increasing the degree of sulfonation, lead to a decrease in the partition coefficient, cellular uptake, and phototoxicity. The quantum yield of singlet oxygen was comparable for all dyes tested in this series, indicating that no significant change in this photophysical parameter resulted from phthalimidomethylation. These results suggest that the addition of 1-2 phthalimidomethyl groups to disulfonated aluminum phthalocyanine improves cellular uptake, but, as the relative efficiency of cell killing was not effected, the intracellular distribution on photosensitive molecules may not be modified.fr
dc.language.isoengfr
dc.relation.ispartofISSN:0031-8655fr
dc.relation.ispartofPhotochemistry and photobiologyfr
dc.subjectPhotocytotoxicity of sulfonated phthalimidomethyl compared to phthalocyaninefr
dc.titleSulfonated phthalimidomethyl aluminum phthalocyanine : the effect of hydrophobic substituents on the in vitro phototoxicity of phthalocyaninesfr
dc.typeArticlefr
udes.description.typestatusPost-publicationfr
udes.description.typepubRévisé et accepté par des pairsfr
udes.description.pages323-327fr
udes.description.period53 (3)fr
udes.description.diffusionDiffusé par Savoirs UdeS, le dépôt institutionnel de l'Université de Sherbrookefr
udes.description.sourcePhotochemistry and photobiologyfr
udes.autorisation.depottruefr
udes.description.ordreauteursPaquette, Benoit; Boyle, Ross W.; Ali, Hasrat; Maclennan, Alexander H.; Truscott, T. George; Van Lier, Johannes E.


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