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    • Induction by estrogens of methotrexate resistance in MCF-7 breast cancer cells

      Thibodeau, Paul A.; Bissonnette, Nathalie; Kocsis-Bédard, Suzanne; Hunting, Darel; Paquette, Benoit (1998)
      Development of drug resistance is a major factor that limits the effectiveness of chemotherapy treatments. In this study, we determined whether estradiol or its metabolites 2-, 4- and 16[alpha]-hydroxyestrone could enhance ...