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dc.contributor.advisorWalti, Hervéfr
dc.contributor.authorBossé, Dominickfr
dc.date.accessioned2014-05-16T12:48:48Z
dc.date.available2014-05-16T12:48:48Z
dc.date.created2009fr
dc.date.issued2009fr
dc.identifier.isbn9780494614884fr
dc.identifier.urihttp://savoirs.usherbrooke.ca/handle/11143/4005
dc.description.abstractBackground : This study aimed to implement low-frequency forced oscillation technique (LFFOT) in neonatal total liquid ventilation (TLV) and to provide the first insight into respiratory impedance under this new modality of ventilation. Method. Thirteen newborn lambs weighing 2.5 « 0.4 kg (mean « SD) were premedicated, intubated, anesthetized, and then placed under TLV using a specially-design liquid ventilator and a perfluorocarbon. The respiratory mechanics measurements protocol was started immediately after TLV initiation. Three blocks of measurements were first performed: one during initial respiratory system adaptation to TLV, followed by two others series during steady state conditions. Lambs were then divided into two groups prior to undergoing another three blocks of measurements: the first group received a 10-min i v infusion of salbutamol (1.5 [micro]g/kg/min) after continuous infusion of methacholine (9 [micro]g/kg/min) while the second group of lambs were chest-strapped. Respiratory impedance was measured using serial single-frequency tests at frequencies ranging between 0.05-2 Hz and then fitted with a constant-phase model. 0.2 Hz harmonic test signals were also launched every ten minutes throughout the measurement protocol. Results. Airway resistance and inertance were starkly increased in TLV compared to gas ventilation with a resonant frequency [less than or equal to] 1.2 Hz. 0.2 Hz resistance and reactance were sensitive to bronchoconstriction and dilation as well as during compliance reduction. Conclusions. We report successful implementation of LFFOT to neonatal total liquid ventilation and present the first insight into respiratory impedance under this new modality of ventilation. We show that LFFOT is an effective tool to track respiratory mechanics under TLV.fr
dc.language.isofrefr
dc.publisherUniversité de Sherbrookefr
dc.rights© Dominick Bosséfr
dc.subjectNouveau-néfr
dc.subjectAgneauxfr
dc.subjectVentilation mécaniquefr
dc.subjectVentilation liquidiennefr
dc.subjectPerfluorocarbonesfr
dc.subjectTechnique des oscillations forcéesfr
dc.subjectMécanique respiratoirefr
dc.titleÉtude de la mécanique respiratoire par la technique des oscillations forcées au cours de la ventilation liquidienne totalefr
dc.typeMémoirefr
tme.degree.disciplinePhysiologiefr
tme.degree.grantorFaculté de médecine et des sciences de la santéfr
tme.degree.levelMaîtrisefr
tme.degree.nameM. Sc.fr


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