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dc.contributor.advisorBkaily, Ghassanfr
dc.contributor.authorAl-Khoury, Johny Jeryesfr
dc.date.accessioned2014-05-15T18:37:50Z
dc.date.available2014-05-15T18:37:50Z
dc.date.created2004fr
dc.date.issued2004fr
dc.identifier.isbn0494002182fr
dc.identifier.urihttp://savoirs.usherbrooke.ca/handle/11143/3357
dc.description.abstractThe objective of this study was to verify whether the response to ET-1 in the intact aorta of a normal hamster is different than that of a CMP hamster and, if so, whether the difference depends on the presence of the vascular endothelium. We also wanted to verify if the contribution of ET-1 receptors (ET[indice inférieur A] and/or ET[indice inférieur B]) in the vascular endothelium and vascular smooth muscle cells (VSMCs) undergoes changes during the development of CMP in the hamster. Our results suggest that there is a difference in the responsiveness to ET-1 stimulation in aortas from CMP hamsters compared to those from normal hamsters. This difference in responsiveness to ET-1 could be due, in part, to an increase in ET[indice inférieur B] receptor density in vascular endothelial cells. This may result in an increase in the synthesis and release of NO that, in turn, produces a large relaxation and opposes the vasoconstrictive effect of ET-1."--Résumé abrégé par UMI.fr
dc.language.isoengfr
dc.publisherUniversité de Sherbrookefr
dc.rights© Johny Jeryes Al-Khouryfr
dc.titleRole of ET-1 and its receptors in the impairment of vascular functions in the cardiomyopathic hamsterfr
dc.typeMémoirefr
tme.degree.disciplineBiologie cellulairefr
tme.degree.grantorFaculté de médecine et des sciences de la santéfr
tme.degree.levelMaîtrisefr
tme.degree.nameM. Sc.fr


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