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Other titre : Conjugated linoleic acid supplementation for 8 weeks does not affect body composition, lipid profile, or safety biomarkers in overweight, hyperlipidemic men

dc.contributor.authorPlourde, Mélaniefr
dc.contributor.otherJoseph, Shama V.fr
dc.contributor.otherJacques, Hélènefr
dc.contributor.otherMitchell, Patricia L.fr
dc.contributor.otherMcLeod, Roger S.fr
dc.contributor.otherJones, Peter J. H.fr
dc.contributor.otherAukema, Harold M.fr
dc.date.accessioned2019-09-05T19:16:28Z
dc.date.available2019-09-05T19:16:28Z
dc.date.created2011fr
dc.date.issued2019-09-05
dc.identifier.urihttp://hdl.handle.net/11143/15971
dc.description.abstractThe usefulness of conjugated linoleic acid (CLA) as a nutraceutical remains ambiguous. Our objective was, therefore, to investigate the effect of CLA on body composition, blood lipids, and safety biomarkers in overweight, hyperlipidemic men. A double-blinded, 3-phase crossover trial was conducted in overweight (BMI $ 25 kg/m2 ), borderline hypercholesterolemic [LDL-cholesterol (C) $ 2.5 mmol/L] men aged 18–60 y. During three 8-wk phases, each separated by a 4-wk washout period, 27 participants consumed under supervision in random order 3.5 g/d of safflower oil (control), a 50:50 mixture of trans 10, cis 12 and cis 9, trans 11 (c9, t11) CLA:Clarinol G-80, and c9, t11 isomer:c9, t11 CLA. At baseline and endpoint of each phase, body weight, body fat mass, and lean body mass were measured by DXA. Blood lipid profiles and safety biomarkers, including insulin sensitivity, blood concentrations of adiponectin, and inflammatory (high sensitiveC-reactive protein, TNFa, and IL-6) and oxidative (oxidized-LDL) molecules, were measured. The effect of CLA consumption on fatty acid oxidation was also assessed. Compared with the control treatment, the CLA treatments did not affect changes in body weight, body composition, or blood lipids. In addition, CLA did not affect the b-oxidation rate of fatty acids or induce significant alterations in the safety markers tested. In conclusion, although no detrimental effects were caused by supplementation, these results do not confirm a role for CLA in either body weight or blood lipid regulation in humans. J. Nutr. 141: 1286–1291, 2011.fr
dc.language.isoengfr
dc.relation.isformatofhttps://doi.org/10.3945/jn.110.135087fr
dc.relation.ispartofISSN:1541-6100fr
dc.relation.ispartofThe Journal of Nutritionfr
dc.rightsAttribution - Pas d’Utilisation Commerciale - Pas de Modification 2.5 Canada*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/ca/*
dc.subjectLDL cholesterol lipoproteinsfr
dc.subjectBody mass indexfr
dc.subjectLinoleic acidfr
dc.subjectFatty acidsfr
dc.subjectOxidationfr
dc.subjectBiological markersfr
dc.subjectBody compositionfr
dc.subjectIsomerismfr
dc.subjectPlasmafr
dc.subjectSafetyfr
dc.subjectSafflower oilfr
dc.subjectinterleukin-6fr
dc.subjectLipidsfr
dc.subjectNutraceuticalsfr
dc.subjectAdiponectinfr
dc.subjectBody fatfr
dc.subjectFasting lipid profilefr
dc.subjectLean body massfr
dc.subjectFatty acid oxidationfr
dc.subjectInsulin sensitivityfr
dc.subjectOverweightfr
dc.titleConjugated linoleic acid supplementation for 8 weeks fails to impact body composition, lipid profile, or safety parameters in overweight, hyperlipidemic menfr
dc.title.alternativeConjugated linoleic acid supplementation for 8 weeks does not affect body composition, lipid profile, or safety biomarkers in overweight, hyperlipidemic menfr
dc.typeArticlefr
dc.rights.holder© Oxford University Press 2011fr
udes.description.typestatusPost-publicationfr
udes.description.typepubRévisé et accepté par des pairsfr
udes.description.pages1286–1291fr
udes.description.period141(7)fr
udes.description.diffusionDiffusé par Savoirs UdeS, le dépôt institutionnel de l'Université de Sherbrookefr
dc.identifier.bibliographicCitationJoseph, S. V., Jacques, H., Plourde, M., Mitchell, P. L., McLeod, R. S., et Jones. P. J. H. Conjugated linoleic acid supplementation for 8 weeks does not affect body composition, lipid profile, or safety biomarkers in overweight, hyperlipidemic men. "The Journal of Nutrition", 141(7), 1286–1291. https://doi.org/10.3945/jn.110.135087fr
udes.description.sourceThe Journal of Nutritionfr
udes.autorisation.depottruefr
udes.description.ordreauteursJoseph, Shama V.; Jacques, Hélène; Plourde, Mélanie; Mitchell, Patricia L.; McLeod, Roger S.; Aukema, Harold M.; Jones, Peter J. H.fr


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