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dc.contributor.authorPlourde, Mélaniefr
dc.contributor.authorChouinard-Watkins, Raphaëlfr
dc.contributor.authorRioux-Perreault, Christinefr
dc.contributor.authorFortier, Mélaniefr
dc.contributor.authorDang, Marie Thuyfr
dc.contributor.authorAllard, Marie-Juliefr
dc.contributor.authorTremblay-Mercier, Jenniferfr
dc.contributor.authorCunnane, Stephen C.fr
dc.contributor.otherZhang, Yingfr
dc.contributor.otherLawrence, Peterfr
dc.contributor.otherVohl, Marie-Claudefr
dc.contributor.otherPerron, Patricefr
dc.contributor.otherLorrain, Dominiquefr
dc.contributor.otherBrenna, J. Thomasfr
dc.date.accessioned2019-08-11T18:03:36Z
dc.date.available2019-08-11T18:03:36Z
dc.date.created2014fr
dc.date.issued2019-08-11
dc.identifier.urihttp://hdl.handle.net/11143/15844
dc.description.abstractBackground: Docosahexaenoic acid (DHA) kinetics appear to change with intake, which is an effect that we studied in an older population by using uniformly carbon-13–labeled DHA (13C-DHA). Objective: We evaluated the influence of a fish-oil supplement over 5 mo on the kinetics of 13C-DHA in older persons. Design: Thirty-four healthy, cognitively normal participants (12 men, 22 women) aged between 52 and 90 y were recruited. Two identical kinetic studies were performed, each with the use of a single oral dose of 40 mg 13C-DHA. The first kinetic study was performed before participants started taking a 5-mo supplementation that provided 1.4 g DHA/d plus 1.8 g eicosapentaenoic acid (EPA)/d (baseline); the second study was performed during the final month of supplementation (supplement). In both kinetic studies, blood and breath samples were collected ≤8 h and weekly over 4 wk to analyze 13C enrichment. Results: The time × supplement interaction for 13C-DHA in the plasma was not significant, but there were separate time and supplement effects (P < 0.0001). The area under the curve for plasma 13C-DHA was 60% lower while subjects were taking the supplement than at baseline (P < 0.0001). The uniformly carbon-13–labeled EPA concentration was 2.6 times as high 1 d posttracer while patients were taking the supplement as it was at baseline. The mean (±SEM) plasma 13C-DHA half-life was 4.5 ± 0.4 d at baseline compared with 3.0 ± 0.2 d while taking the supplement (P < 0.0001). Compared with baseline, the mean whole-body half-life was 61% lower while subjects were taking the supplement. The loss of 13C-DHA through β-oxidation to carbon dioxide labeled with carbon-13 increased from 0.085% of dose/h at baseline to 0.208% of dose/h while subjects were taking the supplement. Conclusions: In older persons, a supplement of 3.2 g EPA + DHA/d increased β-oxidation of 13C-DHA and shortened the plasma 13C-DHA half-life. Therefore, when circulating concentrations of EPA and DHA are increased, more DHA is available for β-oxidation. This trial was registered at clinicaltrials.gov as NCT01577004.fr
dc.language.isoengfr
dc.relation.isformatofhttps://doi.org/10.3945/ajcn.113.074708fr
dc.relation.ispartof0002-9165fr
dc.relation.ispartofThe American Journal of Clinical Nutritionfr
dc.subjectHalf-lifefr
dc.subjectOxidationfr
dc.subjectFish oilsfr
dc.subjectCarbonfr
dc.subjectPlasmafr
dc.subjectCarbon dioxidefr
dc.subjectKineticsfr
dc.subjectElderlyfr
dc.titleKinetics of 13C-DHA before and during fish-oil supplementation in healthy older individualsfr
dc.typeArticlefr
dc.rights.holder2014, Oxford University Pressfr
udes.description.typestatusPost-publicationfr
udes.description.typepubScientifiquefr
udes.description.pages105-112fr
udes.description.period100(1)fr
udes.description.diffusionDiffusé par Savoirs UdeS, le dépôt institutionnel de l'Université de Sherbrookefr
udes.description.sourceThe American Journal of Clinical Nutritionfr
udes.autorisation.depottruefr
udes.description.ordreauteursPlourde, Mélanie; Chouinard-Watkins, Raphaël; Rioux-Perreault, Christine; Fortier, Mélanie; Dang, Marie Thuy; Allard, Marie-Julie; Tremblay-Mercier, Jennifer; Zhang, Ying; Lawrence, Peter; Vohl, Marie-Claude; Perron, Patrice; Lorrain, Dominique; Brenna, J. Thomas; Cunnane, Stephen C.fr


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