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dc.contributor.authorConway, Valériefr
dc.contributor.authorLarouche, Anniefr
dc.contributor.authorPlourde, Mélaniefr
dc.contributor.otherAlata, Waelfr
dc.contributor.otherVandal, Milènefr
dc.contributor.otherCalon, Frédéricfr
dc.date.accessioned2019-08-11T17:59:32Z
dc.date.available2019-08-11T17:59:32Z
dc.date.created2014fr
dc.date.issued2019-08-11
dc.identifier.urihttp://hdl.handle.net/11143/15843
dc.description.abstractEvidences suggest that omega-3 fatty acid (n-3 PUFA) metabolism is imbalanced in apolipoprotein E epsilon 4 isoform carriers (APOE4). This study aimed to investigate APOE genotype-dependant modulation of FA profiles, protein and enzyme important to fatty acid (FA) metabolism in the adipose tissue, the liver and the plasma using human APOE-targeted replacement mouse-model (N=37). FA transport (FATP) and binding (FABP) protein levels in tissues and concentrations of liver carnitine palmitoyltransferase 1 (CPT1) were performed. N-3 PUFA concentration was >45% lower in the adipose tissue and liver of APOE4 mice compared to APOE3 mice. In APOE4 mice, there were higher levels of FATP and FABP in the liver and higher FATP in the adipose tissue compared to APOE2 mice. There was a trend towards higher CPT1 concentrations in APOE4 mice compared to APOE3 mice. Therefore, since APOE-isoform differences were not always in line with the unbalanced n-3 PUFA profiles in organs, other proteins may be involved in maintaining n-3 PUFA homeostasis in mice with different APOE-isoforms.fr
dc.language.isoengfr
dc.relation.isformatofhttps://doi.org/10.1016/j.plefa.2014.09.007fr
dc.relation.ispartof0952-3278fr
dc.relation.ispartofProstaglandins, Leukotrienes and Essential Fatty Acidsfr
dc.rightsAttribution - Pas d’Utilisation Commerciale - Pas de Modification 2.5 Canada*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/ca/*
dc.subjectTransport and binding proteinsfr
dc.subjectn-3 PUFA metabolismfr
dc.subjectCellular FA uptake and degradationfr
dc.subjectAPOE4 carriersfr
dc.titleApolipoprotein E isoforms disrupt long-chain fatty acid distribution in the plasma, the liver and the adipose tissue of micefr
dc.typeArticlefr
dc.rights.holder2014 Elsevier Ltd.fr
udes.description.typestatusPost-publicationfr
udes.description.typepubScientifiquefr
udes.description.pages261-267fr
udes.description.period91(6)fr
udes.description.diffusionDiffusé par Savoirs UdeS, le dépôt institutionnel de l'Université de Sherbrookefr
udes.description.sourceProstaglandins, Leukotrienes and Essential Fatty Acidsfr
udes.autorisation.depottruefr
udes.description.ordreauteursConway, Valérie; Larouche, Annie; Alata, Wael; Vandal, Milène; Calon, Frédéric; Plourde, Mélaniefr


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Attribution - Pas d’Utilisation Commerciale - Pas de Modification 2.5 Canada
Except where otherwise noted, this document's license is described as Attribution - Pas d’Utilisation Commerciale - Pas de Modification 2.5 Canada