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dc.contributor.authorPlourde, Mélaniefr
dc.contributor.otherBrenna, J. Thomasfr
dc.contributor.otherStark, Ken D.fr
dc.contributor.otherJones, Peter J.fr
dc.contributor.otherLin, Yu-Hongfr
dc.date.accessioned2019-08-11T17:50:46Z
dc.date.available2019-08-11T17:50:46Z
dc.date.created2018fr
dc.date.issued2019-08-11
dc.identifier.urihttp://hdl.handle.net/11143/15842
dc.description.abstractFatty acids are among the most studied nutrients in human metabolism and health. Endogenous fatty acid status influences health and disease via multiple mechanisms at all stages of the life cycle. Despite widespread interest, attempts to summarize the results of multiple studies addressing similar fatty acid–related outcomes via meta-analyses and systematic reviews have been disappointing, largely because of heterogeneity in study design, sampling, and laboratory and data analyses. Our purpose is to recommend best practices for fatty acid clinical nutrition and medical studies. Key issues in study design include judicious choice of sampled endogenous pools for fatty acid analysis, considering relevant physiologic state, duration of intervention and/or observation, consideration of specific fatty acid dynamics to link intake and endogenous concentrations, and interpretation of results with respect to known fatty acid ranges. Key laboratory considerations include proper sample storage, use of sample preparation methods known to be fit-for-purpose via published validation studies, detailed reporting or methods to establish proper fatty acid identification, and quantitative analysis, including calibration of differential response, quality control procedures, and reporting of data on a minimal set of fatty acids to enable comprehensive interpretation. We present a checklist of recommendations for fatty acid best practices to facilitate design, review, and evaluation of studies with the intention of improving study reproducibility.fr
dc.language.isoengfr
dc.relation.isformatofhttps://doi.org/10.1093/ajcn/nqy089fr
dc.relation.ispartofISSN: 0002-9165fr
dc.relation.ispartofThe American Journal of Clinical Nutritionfr
dc.subjectMeta-analysisfr
dc.subjectSystematic reviewfr
dc.subjectExperimental designfr
dc.subjectProtocolfr
dc.subjectPlacebofr
dc.subjectSample preparationfr
dc.subjectGas chromatographyfr
dc.subjectFatty acid methyl estersfr
dc.subjectResponse factorsfr
dc.titleBest practices for the design, laboratory analysis, and reporting of trials involving fatty acidsfr
dc.typeArticlefr
dc.rights.holder2018, Oxford University Pressfr
udes.description.typestatusPost-publicationfr
udes.description.typepubScientifiquefr
udes.description.pages211-227fr
udes.description.period108(2)fr
udes.description.diffusionDiffusé par Savoirs UdeS, le dépôt institutionnel de l'Université de Sherbrookefr
dc.identifier.bibliographicCitationJ Thomas Brenna, Mélanie Plourde, Ken D Stark, Peter J Jones, Yu-Hong Lin, Best practices for the design, laboratory analysis, and reporting of trials involving fatty acids, The American Journal of Clinical Nutrition, Volume 108, Issue 2, August 2018, Pages 211–227,fr
udes.description.sourceThe American Journal of Clinical Nutritionfr
udes.autorisation.depottruefr
udes.description.ordreauteursBrenna, J. Thomas; Plourde, Mélanie; Stark, Ken D.; Jones, Peter J.; Lin, Yu-Hongfr


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