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dc.contributor.authorPlourde, Mélaniefr
dc.contributor.authorFreemantle, Erikafr
dc.contributor.authorVandal, Milènefr
dc.contributor.authorTremblay-Mercier, Jenniferfr
dc.contributor.authorCunnane, Stephen C.fr
dc.contributor.otherPoirier, J.fr
dc.date.accessioned2019-08-06T21:37:13Z
dc.date.available2019-08-06T21:37:13Z
dc.date.created2009fr
dc.date.issued2019-08-06
dc.identifier.urihttp://hdl.handle.net/11143/15829
dc.description.abstractOBJECTIVE: To determine whether the metabolism of glucose or ketones differs in the healthy elderly compared to young or middle-aged adults during mild, short-term ketosis induced by a ketogenic breakfast. DESIGN AND PARTICIPANTS: Healthy subjects in three age groups (23 +/- 1, 50 +/- 1 and 76 +/- 2 y old) were given a ketogenic meal and plasma beta -hydroxybutyrate, glucose, insulin, triacylglycerols, total cholesterol, non-esterified fatty acids and breath acetone were measured over the subsequent 6 h. Each subject completed the protocol twice in order to determine the oxidation of a tracer dose of both carbon-13 (13C) glucose and 13C-beta-hydroxybutyrate. The tracers were given separately in random order. Apolipoprotein E genotype was also determined in all subjects. RESULTS: Plasma glucose decreased and beta-hydroxybutyrate, acetone and insulin increased similarly over 6 h in all three groups after the ketogenic meal. There was no significant change in cholesterol, triacylglycerols or non-esterified fatty acids over the 6 h. 13C-glucose and 13C-beta-hydroxybutyrate oxidation peaked at 2-3 h postdose for all age groups. Cumulative 13C-glucose oxidation over 24 h was significantly higher in the elderly but only versus the middle-aged group. There was no difference in cumulative 13C-beta-hydroxybutyrate oxidation between the three groups. Apolipoprotein E (epsilon 4) was associated with elevated fasting cholesterol but was unrelated to the other plasma metabolites. CONCLUSION: Elderly people in relatively good health have a similar capacity to produce ketones and to oxidize 13C-beta-hydroxybutyrate as middle-aged or young adults, but oxidize 13C-glucose a little more rapidly than healthy middle-aged adultsfr
dc.language.isoengfr
dc.relation.isformatofhttps://doi.org/10.1007/s12603-009-0026-9fr
dc.relation.ispartofISSN: 1279-7707fr
dc.relation.ispartofJournal of Nutrition, Health and Agingfr
dc.subjectKetone Bodiesfr
dc.subjectElderlyfr
dc.subjectMetabolismfr
dc.subjectHumansfr
dc.subjectApolipoprotein Efr
dc.subjectDietfr
dc.titleMetabolic response to a ketogenic breakfast in the healthy elderly.fr
dc.typeArticlefr
dc.rights.holderSerdi and Springer Verlag France 2009fr
udes.description.typestatusPost-publicationfr
udes.description.typepubScientifiquefr
udes.description.pages293-298fr
udes.description.period13(4)fr
udes.description.diffusionDiffusé par Savoirs UdeS, le dépôt institutionnel de l'Université de Sherbrookefr
udes.description.sourceJournal of Nutrition, Health and Agingfr
udes.autorisation.depottruefr
udes.description.ordreauteursFreemantle, Erika; Vandal, Milène; Tremblay-Mercier, Jennifer; Plourde, Mélanie; Desgagné, J.; Ryan, MA.; Fortier, Mélanie; Poirier, J.; Cunnane, Stephen C.fr


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