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Effets des paramètres opérationnels sur l'uniformité du mélange dans les mélangeurs à rubans

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MR00237.pdf (20.01Mb)
Publication date
2004
Author(s)
Côté, Pascal
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Abstract
Incomplete mixing of a pharmaceutical blend could result in tablets of non-uniform content. While various blenders are used in the pharmaceutical industry, this particular project focuses on the performance of ribbon blenders. Ribbon blenders consist of a rotating impeller installed within a U-shaped tank. The overall purpose of the study was that of evaluating the effect of ribbon blender operational parameters on the product mixture quality. Mix quality or blend uniformity limits are determined by regulatory bodies. These limits served as targets for blending end-points. In a laboratory-scaled ribbon-blender, powder mixtures composed of white and blue microcrystalline cellulose (MCC) were blended. Blend uniformity was evaluated using a statistical approach under various operating conditions such as loading patterns, blender fill heights, impeller rotational speeds and mixing times."--Résumé abrégé par UMI.
URI
http://savoirs.usherbrooke.ca/handle/11143/1247
Collection
  • Génie – Mémoires [1942]

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