Culture of dimethylhydrazine induced murine angiosarcoma and an evaluation of anti-angiogenic therapy of primary tumor and of tumor metastasis

Abstract

Résumé: Ce mémoire comporte deux parties. La première se rapporte à l'étude de l'induction de la cancérogénèse par le diméthylhydrazine (DMH) et à la mise en culture des cellules endothéliales originant de ces tumeurs. La seconde partie se rapporte à la thérapie anti-angiogénique des tumeurs primaires et métastasiques.||Abstract: This thesis consists of two parts; one deals with several aspects of dimethylhydrazine (DMH) induced carcinogenesis including the culture of DMH-induced endothelial cell (EC) tumors and the second, with anti-angiogenic therapy of primary tumor and tumor metastasis.