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dc.contributor.authorCohen, Alanfr
dc.date.accessioned2018-01-24T17:53:36Z
dc.date.available2018-01-24T17:53:36Z
dc.date.created2017fr
dc.date.issued2018-01-24
dc.identifier.urihttp://hdl.handle.net/11143/11823
dc.description.abstractAbstract: Use of model organisms in aging research is problematic because our ability to extrapolate across the tree of life is not clear. On one hand, there are conserved pathways that regulate lifespan in organisms including yeast, nematodes, fruit flies, and mice. On the other, many intermediate taxa across the tree of life appear not to age at all, and there is substantial variation in aging mechanisms and patterns, sometimes even between closely related species. There are good evolutionary and mechanistic reasons to expect this complexity, but it means that model organisms must be used with caution and that results must always be interpreted through a broader comparative framework. Additionally, it is essential to include research on non-traditional and unusual species, and to integrate mechanistic and demographic research. There will be no simple answers regarding the biology of aging, and research approaches should reflect this.fr
dc.language.isoengfr
dc.relation.isversionofhttps://doi.org/10.1016/j.bbadis.2017.05.028fr
dc.rightsAttribution - Pas d’Utilisation Commerciale - Pas de Modification 2.5 Canada*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/ca/*
dc.subjectAgingfr
dc.subjectComparative biologyfr
dc.subjectComplexityfr
dc.subjectDisposable somafr
dc.subjectDiversityfr
dc.subjectModel organismfr
dc.titleAging across the tree of life: the importance of a comparative perspective for the use of animal models in agingfr
dc.typeArticlefr
udes.description.typestatusPrépublicationfr
udes.description.typepubScientifiquefr
udes.description.diffusionDiffusé par Savoirs UdeS, le dépôt institutionnel de l'Université de Sherbrookefr
dc.identifier.bibliographicCitationCohen, A. (2017). Aging across the tree of life: the importance of a comparative perspective for the use of animal models in aging. Manuscrit soumis pour publication. https://doi.org/10.1016/j.bbadis.2017.05.028fr
udes.autorisation.depottruefr
udes.description.ordreauteursCohen, Alanfr


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Attribution - Pas d’Utilisation Commerciale - Pas de Modification 2.5 Canada
Except where otherwise noted, this document's license is described as Attribution - Pas d’Utilisation Commerciale - Pas de Modification 2.5 Canada