Now showing documents 1-3 of 3
Preparation of conformationally restricted β2,2- and β2,2,3-amino esters and derivatives containing an all-carbon quaternary center
Abstract: β-Amino acids are routinely incorporated into peptidic drugs to increase their stability and to incur conformational biases. However, the synthesis of highly substituted β-amino acids still represents a great ...
General approach toward aspidospermatan-type alkaloids using one-pot Vilsmeier–Haack cyclization and azomethine ylide cycloaddition
Abstract: The development of a new one-pot reaction sequence afforded the tricyclic core of several aspidospermatan-type alkaloids from a linear, densely functionalized substrate. The key sequence features a highly ...
Rapid assembly of quinolizidines via consecutive nucleophilic cyclizations onto activated amides
Abstract: A new approach to the synthesis of quinolizidines involving a cascade of nucleophilic cyclizations triggered by chemoselective amide activation is reported. Particular attention was given to the effect of the ...