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Asymmetric total synthesis of (+)-virosine a via sequential nucleophilic cyclizations onto an activated formamide
Abstract: The first synthesis of tetracyclic alkaloid virosine A is reported. The natural alkaloid was prepared in only 13 steps, in an enantioenriched form. The azabicyclo[2.2.2]octane core was efficiently assembled using ...
Rapid assembly of quinolizidines via consecutive nucleophilic cyclizations onto activated amides
Abstract: A new approach to the synthesis of quinolizidines involving a cascade of nucleophilic cyclizations triggered by chemoselective amide activation is reported. Particular attention was given to the effect of the ...