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Cyclisations de Vilsmeier-Haack et de Mannich en cascade sur un amide chimiosélectivement activé application à la synthèse totale du («)-sécurinol B
(Université de Sherbrooke, 2009)
Les travaux de recherches présentés dans cette thèse ont pour but le développement d'une nouvelle stratégie générale de synthèse d'alcaloïdes polycycliques via une cascade de cyclisations de Vilsmeier-Haack et de Mannich ...
Intramolecular additions of various π-nucleophiles to chemoselectively activated amides and application to the synthesis of (±)-tashiromine
(2006)
Abstract: Vilsmeier-Haack type cyclizations proved to be particularly efficient for generating parts of the polycyclic
cores of many alkaloids, although only monocyclizations have so far been reported. With the goal ...
Synthesis of the tricyclic core of alkaloid securinol B using a cascade of vilsmeier-haack and mannich cyclizations
(2008)
Abstract: The Securinega alkaloids are a family of approximately 20 tetracyclic compounds isolated from diverse Securinega, Phyllanthus, and Margaritaria species of the Euphorbiaceae plant family. Most of these alkaloids ...
Addition of tethered nonaromatic carbon nucleophiles to chemoselectively activated amides
(2005)
Abstract: In an effort to develop new ways of synthesizing polycyclic alkaloids, we successfully added silyl enol ethers, allylsilanes, and enamines to
iminium ions generated from amides. Because of their higher oxidation ...
Rapid assembly of quinolizidines via consecutive nucleophilic cyclizations onto activated amides
(2011)
Abstract: A new approach to the synthesis of quinolizidines involving a cascade of nucleophilic cyclizations triggered by chemoselective amide activation
is reported. Particular attention was given to the effect of the ...
Asymmetric total synthesis of (+)-virosine a via sequential nucleophilic cyclizations onto an activated formamide
(2012)
Abstract: The first synthesis of tetracyclic alkaloid virosine A is reported. The natural alkaloid was prepared in only 13 steps, in an enantioenriched form. The azabicyclo[2.2.2]octane core was efficiently assembled using ...