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dc.contributor.authorLéonard, Guillaumefr
dc.contributor.authorGoffaux, Philippefr
dc.contributor.authorMarchand, Sergefr
dc.contributor.editorUniversité de Sherbrooke. Faculté de médecinefr
dc.date.accessioned2017-03-09T20:21:28Z
dc.date.available2017-03-09T20:21:28Z
dc.date.created2010fr
dc.date.issued2017-03-09
dc.identifierPMID:20728275fr
dc.identifier.urihttp://hdl.handle.net/11143/10169
dc.description.abstractAbstract : Previous human studies have shown that the analgesic effect of high frequency TENS could not be reversed by low doses of naloxone. The aim of the present study was to reinvestigate the possible contribution of opioid receptors in high frequency TENS analgesia by using low (0.02 mg/kg) and high (0.14 mg/kg) doses of naloxone. Naloxone (high and low doses) and saline were administered intravenously to young healthy adults using a double-blind randomised cross-over design. For each visit, TENS (100 Hz, 60 sec) was applied for 25 minutes to the external surface of the left ankle. TENS intensity was adjusted to obtain strong but comfortable (innocuous) paresthesias. Experimental pain was evoked with a 1 cm2 thermode applied on the lateral aspect of the left heel. Subjective pain scores were obtained before, during and after TENS. Because preliminary analyses showed that the order of presentation affected the pattern of results, only the first visit of every participant could be analyzed without fear of contamination from possible carry-over effects. These revealed that TENS maintained its analgesic properties following the injection of saline (p<.001) and the injection of a low dose of naloxone (p<.05). However, when a high dose of naloxone was administered, TENS analgesia was completely blocked (p=.20). These results strongly suggest that high frequency TENS involves opioid receptors. An insufficient amount of opioid antagonist likely prevented previous human studies from discovering the importance of opioid receptors in producing high frequency/ low intensity TENS analgesia.fr
dc.language.isoengfr
dc.relation.isformatofdoi:10.1016/j.pain.2010.07.012fr
dc.relation.ispartofISSN:0304-3959fr
dc.relation.ispartofPainfr
dc.subjectTranscutaneous electrical nerve stimulation (TENS)fr
dc.subjectNaloxonefr
dc.subjectEndogenous opioidsfr
dc.subjectOpioid receptorsfr
dc.titleDeciphering the role of endogenous opioids in high frequency TENS using low and high doses of naloxonefr
dc.typeArticlefr
dc.rights.holder© Lippincott, Williams & Wilkins 2010fr
udes.description.typestatusPost-publicationfr
udes.description.typepubRévisé et accepté par des pairsfr
udes.description.pages1-21fr
udes.description.period151(1)fr
udes.description.sponsorshipFRSQfr
udes.description.sponsorshipIRSSTfr
udes.description.sponsorshipIRSCfr
udes.description.diffusionDiffusé par Savoirs UdeS, le dépôt institutionnel de l'Université de Sherbrookefr
dc.identifier.bibliographicCitationLeonard, G., Goffaux, P., Marchand, S. (2010). Deciphering the role of endogenous opioids in high-frequency TENS using low and high doses of naloxone. Pain, 151(1), 215-219. doi:10.1016/j.pain.2010.07.012.fr
udes.description.sourcePainfr
udes.autorisation.depottruefr
udes.description.ordreauteursLéonard, Guillaume; Goffaux, Philippe; Marchand, Sergefr


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