Show simple document record

dc.contributor.authorLéonard, Guillaumefr
dc.contributor.authorLafrenaye, Sylviefr
dc.contributor.authorGoffaux, Philippefr
dc.contributor.editorUniversité de Sherbrooke. École de réadaptationfr
dc.contributor.editorUniversité de Sherbrooke. Département de pédiatriefr
dc.contributor.editorUniversité de Sherbrooke. Département de chirurgiefr
dc.date.accessioned2017-02-23T19:59:34Z
dc.date.available2017-02-23T19:59:34Z
dc.date.created2012fr
dc.date.issued2017-02-23
dc.identifierPMID:22208674fr
dc.identifier.urihttp://hdl.handle.net/11143/10141
dc.description.abstractPlacebo effects are well-known phenomena in medicine and biology. In fact, placebos are used as control conditions in randomized cross-over clinical trials to validate new treatments. Only recently, however, has it become apparent that the conditioning and/or expectation effects provided by the experience of placebos can influence the results of clinical trials. It seems that combining shams and sequences has prejudiced the conclusions provided by cross-over designs. Frighteningly, this bias is always in the same direction, namely to increase the risk of rejecting potentially valid treatments. New models for clinical trials should be encouraged if we wish to market new and truly valid treatments.fr
dc.language.isoengfr
dc.relation.isformatofdoi:10.1185/03007995.2011.653558fr
dc.relation.ispartofISSN:0300-7995fr
dc.relation.ispartofCurrent medical research and opinionfr
dc.subjectBiasfr
dc.subjectCross-over studiesfr
dc.subjectPlacebo effectfr
dc.subjectPlacebos/administration and dosagefr
dc.subjectRandomized controlled trials as topic/methodsfr
dc.subjectResearch designfr
dc.subjectTranscranial magnetic stimulation/adverse effectsfr
dc.titleRandomized placebo-controlled cross-over designs in clinical trials : a gold-standard to be reassessedfr
dc.typeArticlefr
dc.rights.holder© Taylor and Francis 2012fr
udes.description.typestatusPost-publicationfr
udes.description.typepubRévisé et accepté par des pairsfr
udes.description.pages1-10fr
udes.description.period28(2)fr
udes.description.diffusionDiffusé par Savoirs UdeS, le dépôt institutionnel de l'Université de Sherbrookefr
dc.identifier.bibliographicCitationLeonard, G., Lafrenaye, S., Goffaux, P. (2012). Randomized placebo-controlled cross-over designs in clinical trials : a gold-standard to be reassessed. Current medical research and opinion, 28(2), 245-248. doi:10.1185/03007995.2011.653558fr
udes.description.sourceCurrent medical research and opinionfr
udes.autorisation.depottruefr
udes.description.ordreauteursLéonard, Guillaume; Lafrenaye, Sylvie; Goffaux, Philippefr


Files in this document

Thumbnail

This document appears in the following Collection(s)

Show simple document record