Médecine et sciences de la santé: Documents recently added
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Redirecting splicing with bifunctional oligonucleotides
(2014)Abstract: Ectopic modulators of alternative splicing are important tools to study the function of splice variants and for correcting mis-splicing events that cause human diseases. Such modulators can be bifunctional ... -
The folding of 5′-UTR human G-quadruplexes possessing a long central loop
(2014)Abstract: G-quadruplexes are widespread four-stranded structures that are adopted by G-rich regions of both DNA and RNA and are involved in essential biological processes such as mRNA translation. They are formed by the ... -
A conserved target site in HIV-1 Gag RNA is accessible to inhibition by both an HDV ribozyme and a short hairpin RNA
(2014)Abstract: Antisense-based molecules targeting HIV-1 RNA have the potential to be used as part of gene or drug therapy to treat HIV-1 infection. In this study, HIV-1 RNA was screened to identify more conserved and accessible ... -
Comprehensive secondary structure elucidation of four genera of the family Pospiviroidae
(2014)Abstract: Viroids are small, circular, single stranded RNA molecules that infect plants. Since they are non-coding, their structures play a critical role in their life cycles. To date, little effort has been spend on ... -
Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes
(2015)Abstract: G-quadruplexes (G4) are extremely stable secondary structures forming stacks of guanine tetrads. DNA G4 structures have been extensively studied, however, less is known about G4 motifs in mRNAs, especially in ... -
G4RNA: an RNA G-quadruplex database
(2015)Abstract: G-quadruplexes (G4) are tetrahelical structures formed from planar arrangement of guanines in nucleic acids. A simple, regular motif was originally proposed to describe G4-forming sequences. More recently, ... -
Analysis of small RNA production patterns among the two potato spindle tuber viroid variants in tomato plants
(2015)Abstract: In order to analyze the production of small RNA (sRNA) by viroids upon infecting the plants, the tomato plants (Solanum lycopersicum cultivar Rutgers) were inoculated with the variants of Potato spindle tuber ... -
Small RNA derived from the virulence modulating region of the Potato spindle tuber viroid silences callose synthase genes of tomato plants
(2015)Abstract: The tomato (Solanum lycopersicum) callose synthase genes CalS11-like and CalS12-like encode proteins that are essential for the formation of callose, a major component of pollen mother cell walls; these enzymes ... -
RNA G-quadruplexes and their potential regulatory roles in translation
(2016)Abstract: DNA guanine (G)-rich 4-stranded helical nucleic acid structures called G-quadruplexes (G4), have been extensively studied during the last decades. However, emerging evidence reveals that 50- and 30-untranslated ... -
Development of a highly optimized procedure for the discovery of RNA G-quadruplexes by combining several strategies
(2023)Abstract : RNA G-quadruplexes (rG4s) are non-canonical secondary structures that are formed by the selfassociation of guanine quartets and that are stabilized by monovalent cations (e.g. potassium). rG4s are key elements ... -
Small molecule chaperones facilitate the folding of RNA G-quadruplexes
(2023)Abstract : RNA G-quadruplexes (rG4) have recently emerged as major regulatory elements in both mRNA and noncoding RNA. In order to investigate the biological roles of rG4 structures, chemists have developed a variety of ... -
Global profiling of alternative RNA splicing events provides insights into molecular differences between various types of hepatocellular carcinoma
(2016)Abstract : Background: Dysregulations in alternative splicing (AS) patterns have been associated with many human diseases including cancer. In the present study, alterations to the global RNA splicing landscape of cellular ... -
Global profiling of the cellular alternative RNA splicing landscape during virus-host interactions
(2016)Abstract : Alternative splicing (AS) is a central mechanism of genetic regulation which modifies the sequence of RNA transcripts in higher eukaryotes. AS has been shown to increase both the variability and diversity of the ... -
Linking parental influences and youth participation in physical activity in- and out-of-school : the mediating role of self-efficacy and enjoyment
(2016)Abstract : Objective: Parents influence their children's behavior. We examined parental influence on youth participation in physical activity (PA) in- and out-of-school, directly and/or indirectly, via self-efficacy beliefs ... -
Childhood sports participation and adolescent sport profile
(2017)Abstract : Objectives: We aimed to increase understanding of the link between sport specialization during childhood and adolescent physical activity (PA). The objectives were as follows: (1) describe the natural course of ... -
Étude de la biogenèse et de l’interactome de la ribonucléoprotéine télomérase chez Saccharomyces cerevisiae
Other titre : Study of the biogenesis and interactome of the ribonucleoprotein telomerase in Saccharomyces cerevisiae(Université de Sherbrooke, 2023)Les télomères sont des structures nucléoprotéiques retrouvées aux extrémités des chromosomes eucaryotes linéaires et un certain nombre minimal de répétitions d’ADN télomériques doit être présent afin d’assurer la stabilité ... -
Body image self-conscious emotions get worse throughout adolescence and relate to physical activity behavior in girls and boys
(2022)Abstract : Body image is a commonly-reported factor perpetuating declines in physical activity levels during adolescence. However, the evidence is predominantly qualitative, cross-sectional, and focused on girls. Furthermore, ... -
Physical activity motives have a direct effect on mental health
(2022)Abstract : Physical activity (PA) motives are associated with both moderate-to- vigorous intensity PA (MVPA) and mental health. Studies examining whether PA motives relate directly to mental health or indirectly through ... -
Description of sport participation profiles and transitions across profiles during adolescence
(2022)Abstract : Few studies describe sport participation profiles in the general population using multiple characteristics. Therefore, the objective of this study was to identify sport participation profiles during adolescence ... -
Puberty timing and relative age as predictors of physical activity discontinuation during adolescence
(2023)Abstract : Among same-age adolescents, those who enter puberty relatively later and those who are relatively younger (e.g., born later in the year) might be at greater risk of physical activity discontinuation. This study ...
