Now showing documents 1-6 of 6
Induction by estrogens of methotrexate resistance in MCF-7 breast cancer cells
Development of drug resistance is a major factor that limits the effectiveness of chemotherapy treatments. In this study, we determined whether estradiol or its metabolites 2-, 4- and 16[alpha]-hydroxyestrone could enhance ...
Genomic rearrangements in mouse C3H/10T1/2 cells transformed by X-rays, UV-C, and 3-methylcholanthrene, detected by a DNA fingerprint assay[superscript 1]
Genomic rearrangements occurring in C3H/10T1/2 cells transformed by X-rays were examined with a DNA fingerprint assay. Four multilocus and multiallele probes were employed (M, X, H10, and H16) that detect different families ...
Sulfonated phthalimidomethyl aluminum phthalocyanine : the effect of hydrophobic substituents on the in vitro phototoxicity of phthalocyanines
The photocytotoxicity of sulfonated phthalimidomethyl aluminum phthalocyanine, a more hydrophobic photosensitizer as compared to phthalocyanine substituted with sulfonate groups only, was investigated. Inclusion of 1-2 ...
In vivo enhancement of genomic instability in minisatellite sequences of mouse C3H/10T½ cells transformed in vitro by X-rays[superscript 1]
The level of genomic instability was determined during tumor development in vivo. Genomic rearrangements, a marker of genomic instability, was measured mouse C3H/10T½ cells transforned in vitro by X-rays with a DNA ...
Enhancement of genomic instability by 17[beta]-estradiol in minisatellite sequences of X-ray-transformed mouse 10T1/2 cells
The female hormone 17[beta]-estradiol is involved in the development of breast cancer, an effect usually attributed to its capacity to stimulate the replication of preneoplastic and malignant cells. In this study, we report ...
Biological activities of phthalocyanines-XI. Phototoxicity of sulfonated aluminum naphthalocyanines towards V-79 chinese hamster cells
The phototoxicity of sulfonated aluminum naphthalocyanines towards V-79 Chinese hamster cells is investigated. The disulfonated naphthalocyanine exhibits similar photostability, but better cell penetrating properties ...