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Statistical distance as a measure of physiological dysregulation is largely robust to variation in its biomarker composition
Physiological dysregulation may underlie aging and many chronic diseases, but is chal-lenging to quantify because of the complexity of the underlying systems. Recently, we de-scribed a measure of physiological dysregulation, ...
Detection of a novel, integrative aging process suggests complex physiological integration
Abstract: Many studies of aging examine biomarkers one at a time, but complex systems theory and network theory suggest that interpretations of individual markers may be context-dependent. Here, we attempted to detect ...