Now showing documents 1-5 of 5
Cross-population validation of statistical distance as a measure of physiological dysregulation during aging
Abstract: Measuring physiological dysregulation during aging could be a key tool both to understand underlying aging mechanisms and to predict clinical outcomes in patients. However, most existing indices are either circular ...
Physiological and comparative evidence fails to confirm an adaptive role for aging in evolution
Abstract: The longstanding debate about whether aging may have evolved for some adaptive reason is generally considered to pit evolutionary theory against empirical observations consistent with aging as a programmed aspect ...
A novel measure of physiological condition based on multivariate distance predicts maximal thermogenic capacity and inflammation in a migratory shorebird
Other titre : A novel integrative method for measuring body condition in ecological studies based on physiological dysregulation
Abstract: The body condition of free-ranging animals affects their ability to fulfil their vital needs, their response to stress, their decisions, and ultimately their fitness, with important evolutionary consequences. It ...
Statistical distance as a measure of physiological dysregulation is largely robust to variation in its biomarker composition
Physiological dysregulation may underlie aging and many chronic diseases, but is chal-lenging to quantify because of the complexity of the underlying systems. Recently, we de-scribed a measure of physiological dysregulation, ...
Optimal versus realized trajectories of physiological dysregulation in aging and their relation to sex-specific mortality risk
Abstract: While longitudinal changes in biomarker levels and their impact on health have been characterized for individual markers, little is known about how overall marker profiles may change during aging and affect ...