Now showing documents 1-3 of 3
Aging across the tree of life: the importance of a comparative perspective for the use of animal models in aging
Abstract: Use of model organisms in aging research is problematic because our ability to extrapolate across the tree of life is not clear. On one hand, there are conserved pathways that regulate lifespan in organisms ...
Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins
Abstract : Recent functional, proteomic and ribosome profiling studies in eukaryotes have concurrently demonstrated the translation of alternative open-reading frames (altORFs) in addition to annotated protein coding ...
The risks of one-at-a-time biomarker epidemiology: Associations of circulating calcium levels with age, mortality, and frailty vary substantially across populations
Abstract: Recent studies have shown contradictory associations between calcium levels and health outcomes. We suspected these conflicting results were the consequence of more general issues with how biomarkers are analyzed ...