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Physiological and comparative evidence fails to confirm an adaptive role for aging in evolution
Abstract: The longstanding debate about whether aging may have evolved for some adaptive reason is generally considered to pit evolutionary theory against empirical observations consistent with aging as a programmed aspect ...
Effects of categorization method, regression type, and variable distribution on the inflation of Type-I error rate when categorizing a confounding variable
Other titre : Categorized confounders and type-I error
Abstract: The loss of signal associated with categorizing a continuous variable is well known, and previous studies have demonstrated that this can lead to an inflation of Type-I error when the categorized variable is a ...
Neighbourhood immigration, health care utilization and outcomes in patients with diabetes living in the Montreal metropolitan area (Canada): a population health perspective
Abstract: Background: Understanding health care utilization by neighbourhood is essential for optimal allocation of resources, but links between neighbourhood immigration and health have rarely been explored. Our objective ...
Statistical distance as a measure of physiological dysregulation is largely robust to variation in its biomarker composition
Physiological dysregulation may underlie aging and many chronic diseases, but is chal-lenging to quantify because of the complexity of the underlying systems. Recently, we de-scribed a measure of physiological dysregulation, ...
Homeostatic dysregulation proceeds in parallel in multiple physiological systems
Abstract: An increasing number of aging researchers believes that multisystem physiological dysregulation may be a key biological mechanism of aging, but evidence of this has been sparse. Here, we used biomarker data on ...
Detection of a novel, integrative aging process suggests complex physiological integration
Abstract: Many studies of aging examine biomarkers one at a time, but complex systems theory and network theory suggest that interpretations of individual markers may be context-dependent. Here, we attempted to detect ...