Now showing documents 1-6 of 6
Cross-population validation of statistical distance as a measure of physiological dysregulation during aging
Abstract: Measuring physiological dysregulation during aging could be a key tool both to understand underlying aging mechanisms and to predict clinical outcomes in patients. However, most existing indices are either circular ...
Inflamm‐aging does not simply reflect increases in pro‐inflammatory markers
Abstract: Many biodemographic studies use biomarkers of inflammation to understand or predict chronic disease and aging. Inflamm-aging, i.e. chronic low-grade inflammation during aging, is commonly characterized by ...
A novel measure of physiological condition based on multivariate distance predicts maximal thermogenic capacity and inflammation in a migratory shorebird
Other titre : A novel integrative method for measuring body condition in ecological studies based on physiological dysregulation
Abstract: The body condition of free-ranging animals affects their ability to fulfil their vital needs, their response to stress, their decisions, and ultimately their fitness, with important evolutionary consequences. It ...
A novel statistical approach shows evidence for multi-system physiological dysregulation during aging
Other titre : A novel measurement approach and evidence for multi-system physiological dysregulation during aging
Abstract: Previous studies have identified many biomarkers that are associated with aging and related outcomes, but the relevance of these markers for underlying processes and their relationship to hypothesized systemic ...
Homeostatic dysregulation proceeds in parallel in multiple physiological systems
Abstract: An increasing number of aging researchers believes that multisystem physiological dysregulation may be a key biological mechanism of aging, but evidence of this has been sparse. Here, we used biomarker data on ...
Optimal versus realized trajectories of physiological dysregulation in aging and their relation to sex-specific mortality risk
Abstract: While longitudinal changes in biomarker levels and their impact on health have been characterized for individual markers, little is known about how overall marker profiles may change during aging and affect ...