Now showing documents 1-6 of 6
Cross-population validation of statistical distance as a measure of physiological dysregulation during aging
Abstract: Measuring physiological dysregulation during aging could be a key tool both to understand underlying aging mechanisms and to predict clinical outcomes in patients. However, most existing indices are either circular ...
Inflamm‐aging does not simply reflect increases in pro‐inflammatory markers
Abstract: Many biodemographic studies use biomarkers of inflammation to understand or predict chronic disease and aging. Inflamm-aging, i.e. chronic low-grade inflammation during aging, is commonly characterized by ...
Effects of categorization method, regression type, and variable distribution on the inflation of Type-I error rate when categorizing a confounding variable
Other titre : Categorized confounders and type-I error
Abstract: The loss of signal associated with categorizing a continuous variable is well known, and previous studies have demonstrated that this can lead to an inflation of Type-I error when the categorized variable is a ...
Statistical distance as a measure of physiological dysregulation is largely robust to variation in its biomarker composition
Physiological dysregulation may underlie aging and many chronic diseases, but is chal-lenging to quantify because of the complexity of the underlying systems. Recently, we de-scribed a measure of physiological dysregulation, ...
Homeostatic dysregulation proceeds in parallel in multiple physiological systems
Abstract: An increasing number of aging researchers believes that multisystem physiological dysregulation may be a key biological mechanism of aging, but evidence of this has been sparse. Here, we used biomarker data on ...
Detection of a novel, integrative aging process suggests complex physiological integration
Abstract: Many studies of aging examine biomarkers one at a time, but complex systems theory and network theory suggest that interpretations of individual markers may be context-dependent. Here, we attempted to detect ...