Now showing documents 1-10 of 31
Aging, cognitive decline, apolipoprotein E and docosahexaenoic acid metabolism
Au Canada, 17 millions d’adultes âgés entre 30–64 ans pourraient bénéficier d’une intervention en prévention pour diminuer leur risque de développer la maladie d’Alzheimer (MA). L’un des groupes les plus à risque de ...
Disturbance in uniformly 13C-labelled DHA metabolism in elderly human subjects carrying the apoE ε4 allele
Carrying the apoE ε4 allele (E4+) is the most important genetic risk for Alzheimer's disease. Unlike non-carriers (E4 − ), E4+ seem not to be protected against Alzheimer's disease when consuming fish. We hypothesised that ...
n-3 Fatty acid intake from marine food products among Quebecers: comparison to worldwide recommendations
Objective: To quantify marine food product consumption and EPA + DHA intake among Quebecers, and to compare the results with the most recent recommendations. Design: Data were obtained from a representative cross-sectional ...
Plasma omega-3 fatty acid response to a fish oil supplement in the healthy elderly
Other titre : Plasma response to fish oil in the elderly
Little information is available concerning whether incorporation of dietary omega-3 fatty acids into plasma lipids changes during healthy aging. Elderly (74 ± 4 years old) and young (24 ± 2 years old) adults were given a ...
Docosahexaenoic acid and shore‐based diets in hominin encephalization: A rebuttal
Other titre : Fish and human brain evolution
Carlson and Kingston (: Am J Hum Biol 19:132–141) propose that preformed dietary docosahexaenoic acid (an omega-3 fatty acid in fish) did not have a significant role in hominin encephalization. Their position hinges ...
Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline
Epidemiological studies fairly convincingly suggest that higher intakes of fatty fish and n-3 fatty acids are associated with reduced risk of Alzheimer's disease (AD). DHA in plasma is normally positively associated with ...
Linking low docosahexaenoic acid intake to Alzheimer's disease : caution recommended
Prospective cohort studies and animal models support the concept that low docosahexaenoic acid intake is implicated in the etiology or progression of Alzheimer’s disease. However, other studies crucial to this relationship ...
Disrupted fatty acid distribution in HDL and LDL according to apolipoprotein E allele
Objectives: Omega-3 polyunsaturated fatty acid (ω-3 PUFA) metabolism seems to be disrupted in carriers of the epsilon 4 allele of apolipoprotein E (E4+). The objective of this study was to investigate whether the ω-3 PUFA ...
The loss of P2X7 receptor expression leads to increase intestinal glucose transit and hepatic steatosis
In intestinal epithelial cells (IEC), it was reported that the activation of the P2X7 receptor leads to the internalization of the glucose transporter GLUT2, which is accompanied by a reduction of IEC capacity to transport ...
Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE ɛ4 but not by the common PPAR-α L162V polymorphism in men
The risk of Alzheimer's disease is increased for carriers of apoE4 (E4) or the PPAR-α L162V polymorphism (L162V), but it is decreased in fish and seafood consumers. The link between high fish intake and reduced risk of ...