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Validating metabolic syndrome through principal component analysis in a medically diverse, realistic cohort
Abstract: Background: The concept of metabolic syndrome has been subject to etiological and clinical controversies in recent years. Associations among the five risk factors (obesity, high blood pressure, high blood sugar, ...
The risks of one-at-a-time biomarker epidemiology: Associations of circulating calcium levels with age, mortality, and frailty vary substantially across populations
Abstract: Recent studies have shown contradictory associations between calcium levels and health outcomes. We suspected these conflicting results were the consequence of more general issues with how biomarkers are analyzed ...
Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins
Abstract : Recent functional, proteomic and ribosome profiling studies in eukaryotes have concurrently demonstrated the translation of alternative open-reading frames (altORFs) in addition to annotated protein coding ...
Effects of categorization method, regression type, and variable distribution on the inflation of Type-I error rate when categorizing a confounding variable
Other titre : Categorized confounders and type-I error
Abstract: The loss of signal associated with categorizing a continuous variable is well known, and previous studies have demonstrated that this can lead to an inflation of Type-I error when the categorized variable is a ...
Cross-population validation of statistical distance as a measure of physiological dysregulation during aging
Abstract: Measuring physiological dysregulation during aging could be a key tool both to understand underlying aging mechanisms and to predict clinical outcomes in patients. However, most existing indices are either circular ...
Aging across the tree of life: the importance of a comparative perspective for the use of animal models in aging
Abstract: Use of model organisms in aging research is problematic because our ability to extrapolate across the tree of life is not clear. On one hand, there are conserved pathways that regulate lifespan in organisms ...
Inflamm‐aging does not simply reflect increases in pro‐inflammatory markers
Abstract: Many biodemographic studies use biomarkers of inflammation to understand or predict chronic disease and aging. Inflamm-aging, i.e. chronic low-grade inflammation during aging, is commonly characterized by ...
A novel statistical approach shows evidence for multi-system physiological dysregulation during aging
Other titre : A novel measurement approach and evidence for multi-system physiological dysregulation during aging
Abstract: Previous studies have identified many biomarkers that are associated with aging and related outcomes, but the relevance of these markers for underlying processes and their relationship to hypothesized systemic ...
Physiological regulatory networks: ecological roles and evolutionary constraints
Abstract: Ecological and evolutionary physiology has traditionally focused on aspects of physiology one at a time. Here, we discuss the implications of considering physiological regulatory networks (PRNs) as integrated ...
Physiological and comparative evidence fails to confirm an adaptive role for aging in evolution
Abstract: The longstanding debate about whether aging may have evolved for some adaptive reason is generally considered to pit evolutionary theory against empirical observations consistent with aging as a programmed aspect ...