Abstract: Measuring physiological dysregulation during aging could be a key tool both to understand underlying aging mechanisms and to predict clinical outcomes in patients. However, most existing indices are either circular ...

Abstract: Many biodemographic studies use biomarkers of inflammation to understand or predict chronic disease and aging. Inflamm-aging, i.e. chronic low-grade inflammation during aging, is commonly characterized by ...

Abstract: Many studies of aging examine biomarkers one at a time, but complex systems theory and network theory suggest that interpretations of individual markers may be context-dependent. Here, we attempted to detect ...

Physiological dysregulation may underlie aging and many chronic diseases, but is chal-lenging to quantify because of the complexity of the underlying systems. Recently, we de-scribed a measure of physiological dysregulation, ...