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Cross-population validation of statistical distance as a measure of physiological dysregulation during aging
Abstract: Measuring physiological dysregulation during aging could be a key tool both to understand underlying aging mechanisms and to predict clinical outcomes in patients. However, most existing indices are either circular ...
Inflamm‐aging does not simply reflect increases in pro‐inflammatory markers
Abstract: Many biodemographic studies use biomarkers of inflammation to understand or predict chronic disease and aging. Inflamm-aging, i.e. chronic low-grade inflammation during aging, is commonly characterized by ...
Detection of a novel, integrative aging process suggests complex physiological integration
Abstract: Many studies of aging examine biomarkers one at a time, but complex systems theory and network theory suggest that interpretations of individual markers may be context-dependent. Here, we attempted to detect ...
Statistical distance as a measure of physiological dysregulation is largely robust to variation in its biomarker composition
Physiological dysregulation may underlie aging and many chronic diseases, but is chal-lenging to quantify because of the complexity of the underlying systems. Recently, we de-scribed a measure of physiological dysregulation, ...